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Target 21: corona_TMPRSS2_v1

Tag: boinc:sidock@home
Published 2022-11-17 14:21:56


Dear Participants,

TMPRSS2 is a type II transmembrane protease with broad expression in epithelial cells of the respiratory and gastrointestinal human tracts. It is a cofactor in SARS-CoV-2 entry, and primes viral proteins. Namely, TMPRSS2 cleaves the viral Spro to expose the fusion peptide for cell entry. We are therefore examining TMPRSS2 as a promising strategy to block viral infection in a host-directed therapeutic and/or prophylactic manner. This work is also a a part of larger viral-host protease inhibition study campaign.

With best wishes,
Team SiDock@home


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