base S984 Megaprime
Thylia, a member of the team L'Alliance Francophone found a megaprime for base S984. The prime 160*984^405697+1 has 1.214.252 digits and entered the T5k PrimePages.
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News
411 itemsNews of the research projects that Gridcoin pays for and of the Gridcoin releases, newest first. Press releases that companies pay to publish here are in the list too, marked as sponsored: Gridcoinstats does not write them and does not stand behind what they say.
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latest change to ll-dc app
We have removed the fixed input -v -use NO_ASM in latest WU batch If you are running a 10xx card you must add --passthrough_child -use NO_ASM in app_config.xml to run this on your GPU. For other options like -log xxx you need to change that to --passthrough_child -log xxx //xxx for any value see FAQ to avoid computation errors.
Antibody maturation
Antibodies undergo a process called maturation in which they undergo a series of mutations as they “learn” how to recognize molecules foreign to our body. We’d love to be able to engineer new…
Another new Cunningham project record
NFS@Home again set a new Cunningham project record for the largest penultimate prime factor. 3,709+ factors into 159-digit and 168-digit prime factors, beating the 155-digit record set in April. Congratulations again to all of the project volunteers!
Server move and brief outage
The Bowman lab at U Penn recently underwent a massive migration of our physical hardware.
AI for Cryptic Pockets
Cryptic pockets are of significant interest for drug discovery. These pockets are closed in the snapshots scientists derive from experiments of what a protein typically looks like. However, in…
BOINC Pentathlon
Another year, another BOINC Pentathlon. Once again, welcome back! NFS@Home has been chosen for the Sprint discipline starting May 16 at midnight UTC. Good luck to all! (Including the server!)
Research Update from the MCM Team (June 2026)
We continue to explore genes with top scores in association to lung cancer as part of the Mapping Cancer Markers (MCM) project. This update focuses on the SLC5A1 (solute carrier family 5 member 1) gene. The gene is mainly associated with regulating the uptake of glucose and galactose from the intestine.
New App "ECM P2 (20 GB RAM)" in test
I'm currently testing a new app for ECM which requires up to 20 GB of RAM. If you have such a system and want to help testing, please enable the app in your project settings. Validation and credit granting is not yet implemented for this app.
Markov state models (MSMs)
Folding@home lets us generate a lot more simulation data than is typically possible otherwise. Historically, lots of simulation studies have relied on a few simulations, let’s say one to ten. With…
New Cunningham project record
The recently completed factorization of 12,311- into 155-digit and 181-digit prime factors set a new Cunningham project record for the largest penultimate prime factor. Congratulations to all of the project volunteers!
We haven’t forgotten about you // No nos hemos olvidado de vosotros
Dear volunteers, First of all, please accept my apologies for this long period without any news from us. At the end of last academic year, two events occurred that blocked us from moving forward with the work we were doing in DENIS: on the one hand, Iván finished his grant and started working at a company; and on the other hand, the Rector of the University asked me to take on a Vice-Rector position for this academic year. This latter responsibility has meant that, since the beginning of the…
AI and Folding@home
As artificial intelligence (AI) continues to evolve rapidly, it’s interesting to regularly ask what AI means for Folding@home. In a nutshell, the current state of AI opens up lots of opportunities…
Server upgrade is complete
The server upgrade is complete. Thanks for your patience during the few hours of downtime.
Force field comparisons
One of the big challenges with simulations of protein dynamics is getting enough data. That’s where Folding@home and all of the compute power that you volunteer to dedicate to running simulations…
Server upgrade
The NFS@Home server will be upgraded shortly. During this process, the project may be intermittently offline. An announcement will be posted once the upgrades are complete. We apologize for the inconvenience.
Happy 2026! (belated)
Thanks to everyone who helped get a lot of great science done in 2025! We're looking forward to a great 2026 with you! First, the good stuff! Folding@home is continuing to provide insight into…
Ready again
hi, after speeding up the DB using a special dedicated super fast SSD, now the transition log is cleared and I start again to send WU to client. All seems normal now thanks
New WU
hi, to prevent that credits are not gave due to out of time reached, you should considerate to don't download new tasks until the transitioner queue is empty. Else, in case the queue did not terminate (actually it is still > on one day) fast, I could force to stop download new WU from the server, so you need to have another BOINC connected to process as backup. We can move the DB to special super fast SSD, but before that I would like that old WU where processed in time for give credits. Thanks
New hardware
Hi, during the week there will be a change of server to a new better one. As all about ODLK1 is inside a virtual machine, there are no changes for clients. The unique downside is that operation will takes around 1 hour and in that time ODLK1 will not be reachable. Thanks
Merry Christmas!
Dear project participants! Merry Christmas! I wish you peace and harmony.
Research Update from the MCM Team (October 2025)
As we continue to explore top-scoring genes associated with the development of cancer through the Mapping Cancer Markers (MCM) project, we are excited to share a new research update! This article features NELL2 (Neural EGF-Like-Like protein 2), a gene that plays multiple roles in neural development and cell death regulation.
Catching KRAS in the Act: Simulations Reveal New Paths for Targeted Protein Degradation
Mutations in the KRAS protein are among the most common drivers of human cancers, including lung, pancreatic, and colorectal tumors. Despite decades of effort, KRAS has been considered a particularly…
Quantifying the accuracy of protein simulation models
How do we know our molecular simulation models are accurate? This is a very important aspect of all the work we perform on Folding@home . If we want to use simulations to model the dynamics and…